Tuesday, October 22, 2013

Banding Study of 47,XXY and variants population

 I often allude to a not terribly scientific study that I have done for my own research.  Have no plans to publish, ever.  The study is a composite of more than 400 XXY people from all walks of life, using a variety of treatments including testosterone and estradiol.  They are matched by baseline hormone assay's and placed in percentile groups on a linear chart.  The break down of simple banding into 20th percentiles along that chart clearly demonstrates that there are distinct groups or bands in the XXY population, and one can infer from these bands whom will benefit most from testosterone or estradiol therapy.  It is possible in most cases to infer what gender identity the individual will have, male, female, or intersex.   It is remarkable how little is actually known about people XXY, and it is abundantly clear that the majority of the population is not and has never been male.  Forcing the XXY population into male for the convenience of not really providing treatment has resulted in poor outcomes for the past 50 years.
 Did you know that no one has yet published a study which (including Dr. Klinefelter) actually identifies the 47,XXY and variants population?  
 Klinefelter's studies all describe the natal male and variant population which believes itself to be insufficiently masculine to be male.  His studies rightfully so describe those people to be less than average in most cases in IQ.  These studies have very little to do with 47,XXY people except that some XXY people are affected by Klinefelter's Syndrome also.  
XXY is a genetic marker, just like XX or XY is for natal females or males.  There are females whom are XXY, there are males whom are XXY, and the rest are generally considered to be Intersex in that they live in both gender's.  At the moment the DSM-V takes exception to anyone using the term intersex, because their dichotomy of gender does not allow for fluid existence in more than one.  Most of the documentation, although this is slowly changing, published by the USA National Institutes of Health have been highly negative and severely lacking in facts of any form.  
Can you believe it took the medical community 40 years to finally publish in 2012 the known fact that XXY females exist?  
The medical community has known of XXY females for more than 40 years, but it is an inconvenient fact that normal XXY females can bear children just like ordinary women.  The problem is that they have been pushing all XXY people into a testosterone only forced masculinization program for those 40 years.   And the XXY population except for the 5th banding group has had very bad results, some have died as a result of testosterone use and forced masculinization protocols.
XXY people are not MALE, except for the 5th banding group.
XXY people are not FEMALE, except for the 1st and 2nd banding groups.
XXY people are often INTERSEX, including the 3rd and most of the 4th banding groups.
I've been tracking this data for about a decade, but it would be nice if an agency like the National Institutes of Health would do a formal scientific study on not just a few hundred known XXY cases, but the necessary tens of thousands to establish the population.  Until this is done, all of the work on XXY people as a class are little more than presumptions or are seriously flawed and probably cannot be trusted.

3 comments:

  1. Any chance of a reference list for those of us who are time challenged? :-)

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  2. None at all, I don't use references as my work is based on my work, and a while I could add a few for various comments; Those also are not intended to be copied or published, and without references I have little concern of my comments thus being picked up and republished.

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  3. Makes perfect sense to me Onni,well spoken!

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