Monday, August 9, 2010

XXY: Quality of Life is lower on Androgens... no kidding really?

Quality of life is reduced in patients with Klinefelter syndrome on androgen replacement therapy.

de Ronde W, de Haan A, Drent ML.

Department of Endocrinology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.

CONTEXT: Klinefelter syndrome (KS) is a genetic disorder, characterized by an XXY karyotype, hypergonadotrophic hypogonadism and infertility, which affects approximately 1 in 700 men. KS has also been associated with neuropsychological alterations. OBJECTIVE: To investigate whether quality of life (QoL) is reduced in patients with KS on androgen treatment. DESIGN: Observational study. METHODS: Questionnaires (RAND-36) were sent to 46 KS patients on androgen treatment who regularly visit the outpatient clinic of an academic medical centre. QoL scores were compared with a Dutch male reference group. RESULTS: Forty (87%) questionnaires were returned which were suitable for evaluation. KS patients had significantly lower (worse) scores on eight of the nine domains of the RAND questionnaire compared with the male reference group. In KS patients, higher education was associated with significantly better QoL scores. CONCLUSIONS: QoL is reduced in patients with KS on androgen treatment.

PMID: 19131504 [PubMed - indexed for MEDLINE]Free Article


I read that article and said, "Yep that about sums it up." You can find the article on Amazing that they have finally published what we have known for years, well those of us willing to recognize the problems caused by Testosterone. Its not a panacea, no, Testosterone for people with Klinefelter's Syndrome is one foot in the grave, with the rest of you following in about 10-15 years (or less if you take alot of it).

So Dredger, what does this say about the ethics of giving Testosterone to a patient, is it better that they live first unhappy and then die more quickly? If you didn't know, Dredger is an Ethics specialist and a Eugenicist. We have to watch those doctors who profess to Eugenics very closely, because if you or I do not fit into their perfect world it is perfectly acceptable for them to kill us and still fit into their narrow field as "being Ethical". That is, Death is Ethical if the person who dies isn't considered human. Most of the time we would call such people fanatics, to wit, imagine they happen to be our medical professionals?

Are we safe? Hardly.



  1. I think the sample is far too small to give a proper evaluation, and there are other factors that need to be taken into account, that I'll refer to later after I've read the entire document. It's a pity you don't make it easy and link to the entire article.

  2. When you have the time check out the Denver Study and the current preliminary work published at the KS&A that indicates KS (XXY's) are less able to properly self evaluate, and such reporting is not recommended for these people, and the most common reaction for XXY guys when problems in life occur is to ignore them! And there is nothing in this report about death from taking androgens.

    Plus I have always been taught that a very small population, here 40 KS guys, cannot be compared to a very large group, here 372 XY guys. What would be the results if 40 KS guys were compared to 40 XY hypogonadal guys of similar age and education? A more fair evaluation IMO.

    AND surprise surprise, those on Gel reported lower scores than those on injection and oral preparations, and the higher educated KS guys had the higher scores. So I think this is a resounding thumbs down for this style of research and thumbs up for injectables and oral preparations.

  3. Amazing for someone who pretends to be intersex and pretends to be an intersex expert. I think it shows how FUCKED up in the head he really is.The fact that He continues to attack intersex people and attack Klinefeltners people. It just shows how FUCKED up XXYGuru is and Mentally Unstable he is.

  4. Nicky K D Chaleunphone, aka Razgriz, aka DiaperDragon, aka KamodDraGoon, please do show off your intellectual ability.